| Borrelia Burgdorferi spirochetes with Monoclonal Antibody H9724 from Feta Brain tissue Autopsy--Note: that long and short spirochetes and one cyst form are demonstrated above- CYST FORM AT 9 oclock position |
| Click on images to see more |
Many Images presented on this
site-
are Copyright - by
Other Authors , and other
Publishers
and by
Alan B. Macdonald MD
site-
are Copyright - by
Other Authors , and other
Publishers
and by
Alan B. Macdonald MD
Pathology studies have yielded the following :
1. Borrelia spirochetes in corkscrew form can be
seen in cultures of Alzheimer Autopsy brain.
2. Borrelia spirochetes in corkscrew form are
demonstrated by Monoclonal antibodies in
Alzheimer Autopsy brain. (Link to be completed)
3. Borrelia spirochetes in Granular form are
demonstrated in the GVB hippocampal lesions of
Alzheimer's. (See Poster presentation ICAD 2006)
4. Borrelia spirochetes in Cystic form are
demonstrated in the Alzheimer plaques, and are
demonstrated within Pyramidal neurons of the
Hippocampus. ( See In Situ DNA Images)
5. Whole brain DNA digests of Alzheimer brain
tissue demonstrate Borrelia specific DNA
sequences of Flagellin B spirochetal DNA.
(link to be completed)
1. Borrelia spirochetes in corkscrew form can be
seen in cultures of Alzheimer Autopsy brain.
2. Borrelia spirochetes in corkscrew form are
demonstrated by Monoclonal antibodies in
Alzheimer Autopsy brain. (Link to be completed)
3. Borrelia spirochetes in Granular form are
demonstrated in the GVB hippocampal lesions of
Alzheimer's. (See Poster presentation ICAD 2006)
4. Borrelia spirochetes in Cystic form are
demonstrated in the Alzheimer plaques, and are
demonstrated within Pyramidal neurons of the
Hippocampus. ( See In Situ DNA Images)
5. Whole brain DNA digests of Alzheimer brain
tissue demonstrate Borrelia specific DNA
sequences of Flagellin B spirochetal DNA.
(link to be completed)
| Discussion of Cystic Spirochetes as links to Pick bodies Lewy bodies ALS Spherical Bodies Alzheimer Plaques |
| Email may be sent to: admin@molecularalzheimer.org |
Link to Medical
Hypotheses Website
--Transfection DNA - first report of Borrelia to Human
Transfection with 7 patients showing Flagellin B DNA
inserts in Human Chromosome 11q site
--Plaques of Alzheimer's derived from Cysts of
Borrelia by In Situ DNA hybridization evidence
--Cyst forms of Borrelia as Unifying concept for
Parkinson';s , ALS, Pick's, and other Tauopathies
Click Here
Hypotheses Website
--Transfection DNA - first report of Borrelia to Human
Transfection with 7 patients showing Flagellin B DNA
inserts in Human Chromosome 11q site
--Plaques of Alzheimer's derived from Cysts of
Borrelia by In Situ DNA hybridization evidence
--Cyst forms of Borrelia as Unifying concept for
Parkinson';s , ALS, Pick's, and other Tauopathies
Click Here
| Thank you very much for visiting this site The Research support has been provided by Turn the Corner Foundation, New York ,NY and St Catherine of Siena Medical Center, Smithtown, New York |
DATE OF REVISION
OF THIS WEBSITE
March 15,2007
Click here to see Images from
Spirochetal Hieroglyphics file
OF THIS WEBSITE
March 15,2007
Click here to see Images from
Spirochetal Hieroglyphics file
| Touch the Images with your mouse arrow. Some of the Images will link to additional pictures when you double-click on image |
| Lyme disease in Spinal fluid at Stony Brook Med Ctr followed 8 years later by death from Alzheimer's - case study |
| Spirochetal Forms ( Cystic and Filamentous)inside nerve cells in Alzheimer Hippocampus tissue Click on the Images |
| SHORT COILED BORRELIA BURGDORFERI REFERENCE STRAIN B 31 FROM AMERICAN TYPE CULTURE COLLECTION Contrasted with Very long undulating Borrelia burgd from Autopsy fetal brain tissue stained with Monoclonal mouse Ab H9724 |
| Corkscrew shaped spirochetes are only one of the possible forms that Borrelia may assume: Cystic forms Granular Forms (so called "coccoid ") L forms "Bleb" forms and "Ring "forms also are present in tissues infected with borrelia |
| Cyst form of Borrelia invades a nerve cell in Alzheimer's Disease |
| Ring form and comparison undulating form |
| See Dr Brorson's Cystic Borrelia forms by moving the mouse into this picture |
| Spirochetes inside of nerve cells Harvard McLean Hospital Brain Bank tissue Images - used in Molecular Interrogation study for DNA of Borrelia Alzheimer Disease hippocampal neurons Click here |
| Video of Borrelia spirochetal L form Click to see motile spirochete in spinal fluid from Alzheimer patient |
Concurrent Neocortical Borreliosis and Alzheimer's
disease - Human Pathology 1987
Concurrent Neocortical Borreliosis and Alzheimer's
disease - II- Demonstration of a Spirochetal Cyst
Form - Annals of the New York Academy of Sciences
Click here1987 and 1989 papers on Concurrent
Neocortical Borreliosis and Alzheimer's
disease - Human Pathology 1987
Concurrent Neocortical Borreliosis and Alzheimer's
disease - II- Demonstration of a Spirochetal Cyst
Form - Annals of the New York Academy of Sciences
Click here1987 and 1989 papers on Concurrent
Neocortical Borreliosis and Alzheimer's
| Compare with Relapsing Fever borrelia spirochetes are not as regularly coiled Click here |
| Borrelia and Alzheimer's disease Lecture With all powerpoint slides -Philadelphia 2005 ILADS National Scientific Meeting -CLICK HERE |
| Podcast interview -Clinical Neurology News - First Interview [click here] Borrelia and Alzheimer's disease - Note: The iTUNES program(Free from Apple website ) or Windows Media player installed on your computer - is needed to listen to the interview |
Gestational Lyme Borreliosis article from
Rheum Clinics N America - Click Pregnancy
Rheum Clinics N America - Click Pregnancy
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| Click here ---Diversity of Borrelia Photos Photoessay and quiz |
| Powerpoint slide show - 72 images "Borrelia and Dementia, Medical Hypothesis" Columbia LDA National Scientific Meeting, Philadelphia , Penn October 20, 2006 Images - click here - Adobe format Analysis of Pathology of Alzheimer's disease under the microscope - with connections established to DNA of Borrelia burgdorferi Flagellin DNA - Specifically staining Alzheimer plaques and GVB of Alzheimer's hippocampal neurons. Neurofibrillary Tangles derived from intraneuronal infection by borrelia in the model of SSPE dementia with Alzheimer's tangles in a childhood viral infection dementia. |
| Borrelia Cystic form--- DNA In Situ Hybridization method for staining- Autopsy Case study- Diffuse Lewy body Dementia --Click here to view |
| Paper #5 Medical Hypotheses -- Alzheimer's Neuroborreliosis with Trans synaptic Spread of Infection and Neurofibrillary tangles derived from intraneuronal spirochetes Click here for Abstract |
| "invasion of human neuronal and glial cells by an infectious Strain of Borrelia burgdorferi Microbes and Infection In press Sept 2006Images of infected cells with Annotations - Click here |
| Alzheimer's Disease Round areas of Injury in brain tissue are called Plaques click here to see Alzheimer plaques |
| Comparison of Alzheimer disease Round Plaques with Tertiary Syphilis Infection of human Brain with Round Plaques Identical to Alzheimer Round plaques Click here to See Round Plaques in Syphilis Brain |
| Round areas of brain injury [ Click here to see images] are called Plaques in two Dementia conditions 1. Alzheimer's disease 2. Syphilis ( General Paresis) Rounded profiles of Spirochetes (i.e.) CYSTIC forms cause the Plaques |
| Syphilis Plaques Match Alzheimer plaquesclick here Both plaques in Brain are caused by Spirochetal infection |
| Images on this screen are only a small number of the total images on this website Click the cursor on the image to view another image which is linked to it Also touch the image with the cursor to see another image which is related to it. Click the cursor on the image to see another image which is linked to it also touch the cursor to the image to see a comparison image click the cursor on the image to see another image which is related to it also touch the cursor to the image to see a related image |
| CYSTIC FORM OF BORRELIA at 7 oclock with Red blood cells AND TWO CORKSCREW FORMS(center and 2 oclock positions) |
| Borrelia - 3 forms Cystic (Round) , corkscrew ( spiral) and granular (dot) |
| Borrelia DNA inside of Alzheimer Plaques Click here |
| MANY PROFILES OF BORRELIACLICK HERE TO SEE AN ATLAS |
| click here for Dr P. Collart manuscript (in French) illustration of Granular and Cystic forms of Treponema PallidumBiology of syphilis in French |
| Granular forms of Treponema spirochetes are dot-like particles which can regenerate the entire corkscrew shaped forms click here to see granular forms |
| Granules are or variable size Some are small and other granules are large click here |
| Infectious Alzheimer's - Discussion of evidence from Animal inoculation studies Nature magazine November 2006Click here for link to the article |
| cell wall deficient forms of Borrelia burgdorferi click here to see images |
| Borrelia burgdorferi motile spirochetes in a Laboratory culture click here to view video |
| Research papers (6)--Click here Medical Hypotheses - Draft versions with images obtain all 6 papers in one PDF File |
| Granular (dotlike) spirochetal forms are the spirochetal equivalent of Merozoites |
| Dot like forms of Malaria Parasites are called Merozoites (see position #26) These are the smallest form of the Malaria parasite- Note the diverse forms which malaria parasites demonstrate - in a Life Cycle In like manner the diverse forms of Borrelia spirochetes Spiral/corkscrew, granular dot, Cysts and L forms constitute a Life cycle |
| Video of Alzheimer's due to Infection Click here to view Video |
| Website Statement of Purpose Why are there so many Images and So Little Text ?? Click Here to Read Statement |
| NonCoiled Borrelia spirochetes in Skin CLICK HERE Biopsies of Erythema Migrans from 1983 Berger et al |
| Sample Tissue Histopathology reports for detection of Spirochetes Click here |
| Second Interview with Clinical Neurology News - Podcast Click Here to Listen - Interview #2 |
| Borrelia Attack Models Lecture May 19 2007 University of New Haven Images from Powerpoint Click Here to view |
| Click Here for Images of Biofilms of Borrelia burgdorferi Biofilms of Borrelia burgdorferi in human tissue -An Explanation of microbial persistence in the Human host > Chronic Lyme borreliosis is a biofilm infection |
| Biofilms of Borrelia burgdorferi Lecture - Click Here for Lecture and images July 7,2008 University of New Haven |